In search of a solution to the problem of Alzheimer, an interdisciplinary group of researchers (National Autonomous University of Mexico (UNAM) takes optogenetic stimulation trials, ie genetic and optical methods used in transgenic mice.
Hence, to increase extracellular dopamine concentration in the cerebral cortex of animals in order to assess the likely beneficial effects by stimulation of the dopaminergic system.
The BL-201 lab Neuroscience Division of the Institute of Cellular Physiology (IFC) of the UNAM work with two models, one family type and other sporadic type.
Also in early disease prevention research related to Alzheimer's disease by dopaminergic stimulation, university have proven that prolonged stimulation with that can prevent or reverse memory impairment presenting transgenic mice.
Federico Bermúdez Rattoni, by the laboratory BL-201, Division of Neuroscience, Institute of Cellular Physiology (IFC), said bad progressively affects the brain of patients.
In its early stages alters the function of the cerebral cortex, where recognition tasks as familiarity novelty of stimuli, and the hippocampus, a region associated with spatial localization tasks are performed.
Alzheimer's disease is a progressive neurodegenerative disease and represents the leading cause of dementia and affects both the memory, thinking and behavior of sufferers; the main risk factor for its occurrence is aging.
You can take two forms: familial and sporadic. The first, with an incidence of only two percent, is associated with mutations in patients suffering; the second, at which owns most cases, you do not know how it happens, and as there is no associated mutation comes up unexpectedly.
In the search for a solution to this condition and following mutations related to familial, have developed transgenic mouse models that mimic the development of pathology and memory problems presented by patients.
As we age, the rodents developed the same characteristic that identifies human pathology: accumulation of amyloid-beta peptide and hyperphosphorylated tau protein, said in a statement.
The project involves the referral laboratory and Research Unit and Graduate School of Psychology (FP), where testing performed synaptic function and description of the alterations of the electrophysiological level pathology.
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